Aims

The main goals of the HERCULES sub-study were:

To study the prevalence of hypertension using 24-hour ambulatory blood pressure measurement (ABPM)
To assess renal function using 24-hour urine collection (creatinine clearance, microalbuminuria)
To expand understanding of genetics variants associated with hypertension and renal function within the CoLaus study.

400 subjects of the CoLaus study were randomly selected and investigated on 2 separate occasions.

What data were collected?

The following variables were collected:

Questionnaire including smoking and alcohol consumption, and medication.
24-hour ambulatory blood pressure measurement
24-hour urine collection (day and night separated) with measurement of creatinine clearance, endogenous lithium clearance, urinary sodium, potassium and uric acid excretion and microalbuminuria.
Serum levels of sodium, potassium, creatinin, lithium and uric acid.

Current phase
HERCULES started in 2004. Recruitment was finished in 2009. No follow-up is scheduled. The data have been managed.
400 individuals have participated.