The main goals of the HERCULES sub-study were:
- To study the prevalence of hypertension using 24-hour ambulatory blood pressure measurement (ABPM)
- To assess renal function using 24-hour urine collection (creatinine clearance, microalbuminuria)
- To expand understanding of genetics variants associated with hypertension and renal function within the CoLaus study.
400 subjects of the CoLaus study were randomly selected and investigated on 2 separate occasions.
What data were collected?
The following variables were collected:
- Questionnaire including smoking and alcohol consumption, and medication.
- 24-hour ambulatory blood pressure measurement
- 24-hour urine collection (day and night separated) with measurement of creatinine clearance, endogenous lithium clearance, urinary sodium, potassium and uric acid excretion and microalbuminuria.
- Serum levels of sodium, potassium, creatinin, lithium and uric acid.
HERCULES started in 2004. Recruitment was finished in 2009. No follow-up is scheduled. The data have been managed.
400 individuals have participated.
Prof. Michel Burnier
Prof. Murielle Bochud