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A unique prospective cohort study

By the wealth of data collected and its duration

Presentation

Somatic study

CoLaus|PsyCoLaus aims to better understand cardiovascular disorders (myocardial infarction, stroke) and their risk factors.

Psychiatric study

CoLaus|PsyCoLaus studies psychiatric disorders (such as depression) and their interaction or association with cardiovascular disorders.

By studying the population of Lausanne over a long period of time, CoLaus|PsyCoLaus makes it possible to generate results for disorders associated with the evolution of cardiovascular and psychiatric disorders, such as obesity, hypertension, osteoporosis or sleep apnea.

Data

6734

participants

+ 400

publications (+ 190 co-authored by the CHUV)

150

phenotypes and 12'000 variables

Technical information

Onging study since

2003

Follow-ups every

5 years

Follow-ups in

2009 & 2014

Third follow-up in

2018

Profil

Adult participants aged 35-75 years in 2003

Representative of the Lausanne inhabitants

Study and sub-studies

Ongoing

  • CoLaus (cardiovascular disorders) - 3rd follow-up
  • PsyCoLaus (psychiatric disorders) - 3rd follow-up
  • ActiLaus (physical activity) – 1st follow-up
  • BrainLaus (MRI)
  • Cognition (brain aging)
  • DecibeLaus (noise pollution)
  • GeoLaus (environment and health) 
  • HypnoLaus (sleep disorders) 
  • OphtalmoLaus (ophthalmic disorders)
  • OsteoLaus (bone disorders)
  • PneumoLaus (respiratory disorders)

Closed

  • AngioLaus (arterial phenotypes)
  • Hercules (renal function and hypertension)

Board and committees

Scientific advisory board

The Scientific advisory board includes all investigators of the proposal as well as international specialists with a large scientific experience in cardiovascular and psychiatric epidemiology or population genetics. The committee met jointly with the scientific committee yearly in order to assure the scientific progression of the project and to enhance international collaboration.

Local steering committee

The Local steering committee oversees data collection (including the training and supervision of staff involved in the ascertainment of subjects), data management and the transfer of data to collaborating centers. It also assures that the biobank is run according to current legal dispositions and to the rules of the Swiss Academy of Medical Sciences (SAMS). In particular, the steering committee is in charge of controlling that analyses of samples are performed within the limits of the consent form signed by each participant and according to the protocol and its amendments approved by the local ethic committees.

Scientific committee

The Scientific committee includes all investigators of the proposal. The committee meets once a year and is in charge of the scientific aspects of the project and assures its multicenter character. Specifically, this committee decides on the timing and distribution of analyses across centers. It also supervises the local steering committee to assure recruitment progression and evaluates the feasibility and scientific value of complementary subprojects submitted by researchers from outside, intending to use parts of collected follow-up data. The meetings have taken place yearly since 2009.